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Research Publications Data & Code About Contact

Research Publications Data & Code About Contact

Precision oncology lab at City of Hope
cancer systems biology | bioinformatics | machine learning

Welcome to the Nath lab homepage!

We study mechanisms of tumor evolution, cancer progression, and drug resistance using bulk and single-cell omics data. We also develop AI/ML-guided predictive biomarkers and treatment stratification strategies to improve cancer patient care.

Featured publications

Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer
Topics: single-cell RNA sequencing (scRNA-seq), NGS, systems biology, machine learning, ovarian cancer
Discovering long noncoding RNA predictors of anticancer drug sensitivity beyond protein-coding genes
Topics: drug response prediction, machine learning, pharmacogenomics, long non-coding RNAs (lncRNAs)
Leveraging Single-Cell Approaches in Cancer Precision Medicine
Review: single-cell sequencing technologies, tumor heterogeneity, clonal evolution, biomarkers, tumor microenvironment
Palmitate-Induced IRE1–XBP1–ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell Migration
Topics: cancer cell signaling, cell adhesion, migration, ER-stress, palmitate